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Treatment of Premature Ejaculation
Serotonergic Antidepressants

Several scientific articles and reviews have addressed the use of serotonergic drugs in treating patients with premature ejaculation. Data earlier than 1995 on the use of clomipramine were reviewed by Althof and by Harvey and Balon. These data indicate that clomipramine at doses from 25 to 50 mg is effective in prolonging the intravaginal intercourse to at least two minutes in about 70% of men, compared to a 10% improvement in patients treated with placebo. Further, a study by Segraves et al. suggested that the intake of clomipramine could be limited to the day of intercourse. The minimum time between drug ingestion and maximum ejaculatory control, however, has not yet been fully established.

A prospective, doubleblind, placebo-controlled, cross-over design study examined the effect of 25 mg clomipramine, ingested as needed, 12 to 24 hours before anticipated sexual activity (coitus or masturbation) was evaluated in eight patients with primary premature ejaculation, six with combined premature ejaculation and ED, and eight controls. Significant increase in ejaculatory latency from two to eight minutes was reported by men with primary premature ejaculation but not by the other two groups of patients. Clomipramine inhibited nocturnal penile tumescence in all subjects. Moreover, the mechanism(s) by which clomipramine retards the ejaculatory latency is not totally clear. Clomipramine is a tricyclic antidepressant, which also acts centrally at the 5-HT-2 receptor to inhibit serotonin reuptake and thus promotes serotonin activities. Some studies have suggested, however, that clomipramine increases the sensory threshold for stimuli in the genital area, possibly through the inhibition of the adrenergic receptors in the peripheral sympathetic system. The effect of clomipramine on sexual function is not always consistent, and both spontaneous orgasms and ejaculation and anorgasmia have been reported to occur in some patients. Painful ejaculation is another possible side effect to the intake of clomipramine.

SSRIs, have also been used to treat premature ejaculation. Similar to clomipramine, these agents also have the potential for inducing variable effects on sexual function, including spontaneous orgasms and ejaculation, anorgasmia, or painful ejaculation. Further, the earlier reports on treatment of premature ejaculation with antidepressants have been criticized by Althof for the following reasons:

1. relying on the subject’s selfreport of ejaculatory latency;
2. inconsistent adherence to strict controls, dosages, washout periods, or investigator blindness;
3. lack of long-term follow-up;
4. lack of determination of drug effects on psychosocial or other sexual parameters;
5. lack of distinction between life-long and acquired conditions.

More recent reports have been placebo controlled, and one study measured penile sensory threshold, sacralevoked response, and cortical somatosensory-evoked potential testing to gain insight into the mechanism of drug action. In this study, fluoxetine increased the penile sensory threshold, without changing the amplitude and latencies of sacral-evoked response and cortical somatosensory-evoked potential.

Also you can use Viagra with Priligy in Australia to treat premature ejaculation and make your sexual life brighless. Viagra (sildenafil) is indicated for the treatment of erectile dysfunction, defined as the inability to achieve and maintain penile erection required for successful intercourse.

α-Adrenergic Receptor Blockers

The use of α-adrenergic receptor blockers to delay premature ejaculation is based on the understanding that the sympathetic nervous system is responsible for the peristaltic movement of the seminal fluid through the male genital tract. Shilon et al. administered phenoxybenzamine to nine men with premature ejaculation, seven of whom reported an increase in their ejaculatory latencies. Cavallini reported the effects of treatment with two other α-1-blockers (alphuzosin and terazosine) on premature ejaculation in 91 men who were resistant to psychological therapy. The study was a double-blind, placebo-controlled, cross-over in which each drug and placebo were administered for two months. Approximately 50% of patients and their partners reported improved ejaculatory latencies for both α-blocking agents, as compared to approximately 13% for patients on placebo. Side effects, mainly hypotension and epigastric pain, were experienced by about 5% of patients on active drug. Another side effect of α-receptor blockade reported in the above referenced study with phenoxybenzamine is dry ejaculation (ejaculation without expulsion of the seminal fluid). These preliminary studies suggest that the effectiveness of α-blockers in treating premature ejaculation is close to that seen in treatment of benign prostatic hyperplasia. The final assessment of the role of α-receptor blocking agents in treating premature ejaculation, however, must await the results of large well-controlled trials to examine both efficacy and safety of long-term use.

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What the heck is Viagra?

Viagra is known as a widely used life-style pill employed simply because treatment to help you erection problems. This unique medication is definitely at the start designed to add to the the flow of blood using areas of the body and also unwinds muscle tissue. Now, the actual narcotic aids men with their erection problems. For that reason, buy Viagra can be useful for further more strengthening your self confidence. Considering the fact that creating a satisfactory love-making life’s vital concerning guys, buy viagra is a better pharmaceutical selection of almost all adult males today.Famous for its health and safety and even performance, Viagra is advised to men a variety of ages. Nonetheless, the intake of the following medication really should be driven by an authorized in addition to certified physician considering diagnosing erection problems is required.Viagra remains safe and secure to get considered through men that are usually given by doctors for taking other types of prescription drugs. Your mentioned substance doesn’t have any negative conversation utilizing certain medicine regarding despression symptoms as well as high blood pressure levels. Having said that, Viagra is not dependable for being used along with medication which contain nitrate. Where you should buy Viagra prescription drugs?When your physician will give you the rule to look at Buy Viagra, purchase together with buy the idea for sometimes native drugstores and also certified drugs online. Buying Viagra with drugs online is the better choice for nearly all gentlemen, as it would be an increasingly suitable, simpler, in addition to swifter technique for buying your required relief medication.Yet, you have to be very careful in order to pick which blog for getting Viagra via, for the net can be crowding along with dodgy druggist which will promote infected prescription drugs as well as prescription drugs with their people.

Decide to arrangement and obtain such type of life-style pill on sanctioned plus professional World-wide-web druggist to prevent well being risks and funds deficits. Discomfort Viagra taken?Buy Viagra need to be used the same manner it had become determined by a qualified medical doctor and also medical practitioner. Never absorb it large dosages or for an extended length of time than the g . p recommends. Consumption with Viagra in fact changes based on somebody’s ongoing impotence problems issue. Additionally, take into account that Viagra is effective when you can find sex-related pleasure. Consequently impotence is not possible merely by simply take in of your Viagra medicine. Never expect more durable if you have very little bricks-and-mortar enjoyment. What are the unintended effects with Viagra?Very much like other styles for relief medication, Viagra has proven to offer prominent unwanted effects. Medical doctors endorse an instant bring to an end utilizing Viagra in addition to seek medical treatment anytime allergic attacks such as lump involving language, mouth, can range f, and also experience instantly manifest. Cease regarding Viagra daily allowance is likewise well-advised in order to men who working experience numbness, vertigo, along with prickling with the arms and neck throughout gender.Non-serious adverse reactions for Buy Viagra include the adhering to: 3 . Annoyance * Back pain 6 . Disappointed abs 2 . Inflammation and even high temperature inside the pectoral and even neck of the guitar.

In the entire history perhaps there wouldn’t be happen before that other drug has achieved as much as fame as Viagra. Made to cure impotency, this drug has developed by the pharmaceutical giant Pfizer- has achieved great status, with sales of over hundreds of thousands of pills everyday. The success of Viagra itself shows the ratio of cure among men all over the world.

However, ancient sciences like Ayurveda and Unani have been known and practiced several natural medicines for treating impotency since centuries and that too with positive results. These therapies are herbal and most of them have been proven for their influence in the western world too.

But before seeking information of the natural cure options present for impotence, let’s see what the real Viagra does. When it is consumed, it helps the blood flow on the corpus cavernosa of the penis. The corpus caversona is composed of several spongy tissues. When these spongy tissues are mix with blood, the penis becomes hard.

There is some disadvantage when a person consumes Viagra. One of the main reasons is that Viagra needs to be continuously used to obtain an erection. And those who use Viagra know how expensive the Viagra is. Health wise Viagra can produce common colds, headaches, etc. Prolonnged use of Viagra can cause loss of peripheral vision and also total blindness. There have also been found that a men suffering from heart attacks when having sexual intercourse under the effect of Viagra.

This made doctors as well as users to keep seeking for alternatives to Viagra; this has made herbal supplements more famous amongst people. However, now that we know that several herbal supplements exist for the treatment of Viagra, let us see how they affect the male penis. All these are carefully created preparations by mixing just the right amounts of several herbs and then carrying out several herbs and carrying out several processes for blending them. Since the name Viagra has become so ordinary, these preparations are called as herbal Viagra, though they have nothing to do with Viagra. Viagra is a chemical drug, herbal Viagra are prepared by herbal constituents.

But similar to original Viagra, the herbal Viagra work in two ways:

(i) They improve the circulation of blood to the penis and

(ii) they alter the hormones so that the male has better libido.

Herbal supplements are used for the treatment of not just impotence, but several other male sexual problems such as weak libidos, penis curves, penis enlargement, premature ejaculation, etc.

But some safety should to be use. Initial and foremost, if you are suffering from hypotension, you need to consult with an Ayurvedic doctor. Some people claim that since herbal Viagra change the hormonal balance of the body. This is true if the herbal Viagra are taken for a long time. Some components of the herbal Viagra can also cause dyspepsia, depression, colds, headaches etc.

If you are wondering why the title reads ‘Generic Viagra and erectile dysfunction’ instead of plainly using Viagra, let’s clarify one thing here. For starters, I don’t differentiate between generic Viagra and brand-name Viagra a tad bit. I am the kind of a guy that wants to go by what the experts and many at the FDA tell having tested both of them thoroughly. Secondly, I am more driven away by the hate campaign by those marketing people representing a large group which includes the makers of original Viagra to keep generic Viagra at bay and out of reach of those millions of frustrated night souls.

I believe it is relevant to look a little deeper into the therapeutic mechanisms of how generic Viagra functions. The basic mechanism of erectile function is the ability of male adults to develop and maintain penile erection. As it is known very well, a number of factors contribute to have the penis ready for sexual act and a few important of them include a healthy cardiovascular system, optimal neurogenic order, right hormonal balance and a healthy functioning of penile muscles called as corpora cavernosa.

Treating erectile dysfunction with generic Viagra takes care of increasing blood circulation to corpora cavernosa and helps keep it there sufficiently long enough for intercourse. The natural blood circulation to the penis is insufficient in those people suffering from ED due to various reasons which we have already seen above. But this is more in adults who are past their middle age or having diabetes mellitus. Diabetes tends to damage the inner walls of blood vessels thus failing to supply enough blood to corpora cavernosa muscles. As if this was not enough, the damaged blood vessels are not in any position to hold whatever blood they supplied and as the blood leaks out of penile muscles you tend to loose whatever little erection you had.

There are two important facts to know about Viagra or generic Viagra at this stage. Generic Viagra, like its original drug which falls into oral treatment category, is designed to give a temporary relief long enough for intercourse. Generic Viagra works on penis erection mechanism and not on the cause of the problem which needs to be thoroughly examined.

Your doctor may decide on prescribing you with this oral drug based on certain examinations although there are not many specific tests to determine erectile dysfunction. The first and the fundamental of them is blood test to identify possible causes like diabetes and hormonal imbalances. Before Viagra or generic Viagra can be taken, you doctor may want to test you for all types of cardio vascular diseases, diabetes, etc.

Viagra or generic Viagra works very well on both cases of psychologically as well as physiologically induced erectile dysfunction. Your physician may ask a few simple questions to determine whether yours is physiological or psychological, such as whether you ever had erection. Those who never had any erection at all in their lives, they are least likely to have a psychological problem causing erectile dysfunction.
This may not alter the decision to prescribe generic Viagra but gives insights to a broader array of treating the problem for permanent solution.

Viagra Soft Tabs is a sublingual tablet. It is absorbed directly into the bloodstream; therefore it starts to act faster and requires a much smaller dosage of the chemical agent to achieve the result. Thus the effects occur within about 20 minutes instead of 60 minutes or more like in the case of regular Viagra.

Impotence or Erectile Dysfunction is a consistent inability to sustain an erection sufficient for sexual intercourse. It can be a total inability to achieve an erection, an inconsistent ability to do so or a tendency to sustain only brief erection. Impotence usually has a physical cause, such as disease, injury, or drug side effects. Any disorder that impairs blood flow in the penis has the potential to cause impotence. It rises with age. About 5 percent of men at the age of 40 and between 15 and 25 percent of men at the age of 65 experience impotence.

Viagra soft tabs 100mg brand name Viagra and generic viagra that have been used in order to treat problems such as impotence in men. While these personal problems may cross over into other areas of the man’s life outside the bedroom, the hope and confidence that can be brought back into the man’s life as a result of this drug can improve his entire living status. Viagra soft tabs 100mg and brand name Viagra drugs all exist to help solve the man’s problems and get him back to his confident and capable self. They fight erectile dysfunction, or ED.Viagra Soft Tabs are oral lozenges containing quick-dissolving compounds. As with the standard Viagra, Viagra Soft Tabs will stimulate the dopamine receptors in the hypothalamus and mid-brain, enhancing the natural erection process.Excitory signals are then transmitted down the spinal cord to the sacral parasympathetic nucleus, stimulating parasympathetic activity of the sacral nerves supplying the penis. The penile smooth muscle then relaxes, and the pelvic arteries dilate. Dilated arteries of the penis fill with blood, and corpora cavernosa engorges, and the penis becomes erect. However, generic versions of drugs are typically much cheaper. Viagra Soft Tabs is an oral drug used to treat male impotence. Viagra Soft Tabs are quick-dissolving lozenges for treating male impotence. Comparing to ordinary Viagra, Viagra Soft Tabs has reduced the start time from 30 to 15-19 minutes with the effective duration of 5 to 6 hours per dose. It relaxes the blood vessels in the penis.The allows blood to flow into the penis causing an erection and you get a harder, longer-lasting erection.Your feelings, your sexual desire are still very important. Although Generic viagra soft tabs can be taken safely by most men, viagra soft tabs isn’t suitable for everyone and doesn’t work in all cases. Soft Tabs Viagra are oral lozenges containing quick-dissolving compounds. Ask your doctor before taking viagra soft tabs. If there’s a risk of a certain side effect for you, your doctor can advise you of other effective treatment options. If you are over sixty years of age, your doctor may prescribe a lower dose of this medication. Most of known side effects are generally mild and brief, but in some cases Generic viagra soft tabs can cause some side effects which may be intense. Some common and uncommon side effects of viagra soft tabs are headache, nasal congestion, flushing or blushing to the face or neck, stomach discomfort, bladder pain, an allergic reaction.

What exactly are the key benefits of possessing Viagra?

Viagra can be a new technology extra-strength prescription medication that is certainly taken orally to the remedy of erectile dysfunction. It tackles male impotence by escalating the all-natural blood circulation to your penis, permitting impacted guys to appreciate extended and much better erections when sexually aroused.

There are numerous very good causes for getting Viagra as for each proposed by your health care supplier, to heal erectile dysfunction and impotence in male. You are able to purchase Viagra on-line from a secure and certified on the web pharmacy, that will carry out a web-based consultancy to find out in case you are suited for your drug or not.

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Acquiring Viagra on the web securely

If you are searching to get Viagra on the web securely, you need to guarantee that your picked on the web pharmacy dispenses protected and genuine medicines and can only market you Viagra on-line following you might have taken a web based consultation. Viagra can be a prescription only drug. Web sites that enable you to acquire Viagra with out using an internet consultation arent genuine so you must not acquire with them.

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Is generic Viagra value making use of?

There is certainly no promise that Generic Viagra will function and its elements is likely to be unidentified, leaving you at risk of possible well being hazards. Getting Viagra on-line to heal erectile dysfunction and impotence over the web with out a prescription could confirm even riskier.

There are tons of counterfeit medicines within the industry that can do severe harm to an people wellbeing. There arent any recommendations beneath which these medicines are created and saved and theyre unlawful. The truth that you should buy this medicine with no extensive check-up, without having even a blood pressure level looking at, from a registered healthcare practitioner speaks badly for generic medication.

Cialis and Viagra are both medications that have been approved by the FDA for use to correct erectile dysfunction in millions of men. Viagra, manufactured by Pfizer and Cialis, manufactured by Eli Lilly both bring hope to the table for so many. Viagra was introduced first, followed by Cialis and although they are basically one in the same many have remained loyal to Viagra and do claim that it is stronger or works better. Cialis has put quite a twist on erectile dysfunction drugs when Eli Lilly introduced it and announced that it could help a man obtain and maintain an erection for up to 36 hours versus Viagra’s four hours. Cialis also came forward with what is called Daily Cialis. This can be taken as part of a man’s daily regimen, the dose is cut down to 2.5mg’s and constantly remains in the bloodstream offering an amazing breakthrough that while Cialis is sometimes called the “weekender” it can now offer restriction free options in regards to sexual activity. A man could now get erect anytime if sexually excited or stimulated.

Cialis and Viagra are both compromised of PDE5 inhibitors and both host the same side effects and conditions to determine eligibility for taking the drugs. Viagra, nicknamed the “little blue pill” and Viagra, nicknamed the “weekender.” Comparing Cialis and Viagra just a bit more, in 2004 $1.7 billion worth of Viagra was sold. In that same year $272 million was sold of Cialis. Viagra has opted to use a spokesperson for their drug but Cialis chose not to use one at all. There is no real price difference between Cialis or Viagra but Viagra is known for lasting about four hours and Cialis is known for lasting up to 36 hours. Google hits reflect that more people are searching the web for Viagra than for Cialis.

There is much evidence to indicate that Cialis is catching up and may soon surpass Viagra. In France Cialis has already knocked the socks off of Viagra. Viagra has more of a reputation since it has been effective and around for longer than Cialis. There is no doubt that Viagra has been trusted by millions of men but Cialis offers spontaneity to millions of men because it gives them that 36 hour window to play with and they are no longer stuck having to give it their best shot within four hours.